I have just completed the Tetherex nasal vaccination study. I am going to make a separate post about taking part in medical trials, but I wanted to write a quick post about the Tetherex vaccine and my experience being one of the first people in the world to be vaccinated with this new method.

What Is The Tetherex Vaccine?

The Tetherex vaccine uses the novel single-cycle adenovirus vaccine platform, developed by Mayo Clinic, to enhance the expression of target antigens, amplifying immune responses to infectious disease targets. Studies show that the single-cycle adenovirus can increase target antigen expression up to 100-fold, compared to current replication defective adenovirus vaccines.

The exciting aspect of the Tetherex vaccine is delivering it nasally. Administering the vaccine via the same route that the virus uses to get into our bodies, may result in more effective protection.

How Was The Tetherex Vaccine Administered?

The Tetherex vaccine was administered nasally, a first of its kind. It was only slightly uncomfortable – CV19 tests are more much less comfortable. The vaccine was injected using a separate syringe for each nostril. On each, occassion some of the liquid ran down the back of my throat and I could smell and taste it slightly. It was sweet, not at all unpleasant.

The vaccine was administered in 2 doses, 5 weeks apart. Being part of a study, I was required to wait 4 hours after dosing before I could. During this time I was fed (they catered for my plant-based diet), checked over by a doctor and nurses several times (ECG, vital signs, check of my nose, etc), and rested.

I then had to complete an online diary and check my temperature at the same time each night. I also had to make multiple follow-ups where I went through most of the same health checks as dosing day.

What Were The Side Effects?

I can’t say what side effects may be experienced by others – I can only speak about my own experience..

I was a bit fatigued after the first dose, but I believe this was more likely due to the large amount of blood they siphoned out of me. During an unrelated medical study, I partook in fortnightly blood tests. On each occassion I wanted to curl up into a ball and pass out for the rest of the day.

The blood taken from me after each dose was (I guesstimate) about three times as much as the blood tests in the prior study. I was also fasted for over 12 hours, so I’m fairly confident that’s why I was tired, rather than the vaccine, but I can’t say for sure.

The morning following my first dose, I did have a slightly sore throat and clear phlegm, accompanied by a blocked nose. This went away by midday and didn’t return, even after the second dose.

There was no pain at the injection site. Having since received the Pfizer jab so that I am not affected by Queensland’s Orwellian laws, I know how painful the injection site can get. If the sore-arm became a sore face, no-one would get it. Luckily, that wasn’t an issue. There was no pain at all.